Our Portfolio

Our investment analysts have taken thousands of companies through our pipeline to build a portfolio of cutting-edge science and technology start-ups.


Our diverse portfolio includes companies in all stages of development. As a fully committed partner, we have helped numerous companies grow rapidly and achieve successful milestones.


At UPMC Enterprises, we support several initiatives that enable and expand our portfolio of commercial businesses.


Our Portfolio

Xealth Helps UPMC Make Digital Solutions a Reality

Providing patients with a meaningful experience has always been a primary goal for UPMC. So, when the company began exploring ways to improve the digital experience for both patients and clinicians by digitizing the collection of pre-procedural materials for Orthopedics, it surprised no one when they made it a top priority to find a partner who shared similar thinking.

Using RxAnte Helps UPMC Health Plan Improve Medical Adherence, Star Ratings

As part of the top-ranked UPMC health system, UPMC Health Plan takes a comprehensive approach to Star Ratings. That approach includes integrating clinical data from the health system with claims data from the insurance side of the business. By doing this, the organization takes a broad-based approach to improve patient care and health outcomes. For example, UPMC uses its clinical pharmacy initiatives to steer members to participate in care and/or disease management programs.

Prodigo Solutions Improves UPMC Procurement Efficiencies and On-Contract Purchases.

As an integrated delivery and finance system, UPMC’s supply chain must serve more than 30 hospitals, hundreds of physician practices and outpatient clinics, and the largest health insurer in Western Pennsylvania. Altogether, the system has more than 80,000 employees.

Health Catalyst CORUS Suite Helps UPMC Improve Clinical and Financial Outcomes

Health care costs are continuing to climb and many Americans are beginning to think that they aren’t getting their money’s worth. However, much of these cost increases come directly from a lack of understanding about how much it costs to provide patient care and a lack of knowledge about how those costs compare to the outcomes achieved. If health care organizations want to build sustainability, they must first identify and address waste, and reduce the total cost of care by creating efficiencies.

Evolent and UPMC Collaborate to Expand Value-Based Care

In the early stages of development, Evolent Health understood that the transition to value-based care created a great opportunity for organizations, including health systems, independent practice associations, accountable care organizations, and health plans.

UPMC and Cavulus: Defining the Next Generation of Medicare Advantage Technology

Some Medicare Advantage (MA) plans reduce cost by retrofitting commercial insurance software or agnostic technologies to support their Medicare line of business. Unfortunately, this often results in extensive implementations that exceed budgets, resources, and reduce their competitive advantage.

UPMC and Health Fidelity Partnership a Win-Win for Risk Adjustment

When Health Fidelity was founded, the tech startup’s goal was to provide organizations with a best-in-class clinical natural language processing (NLP) and inference platform. The company’s tech could be used to analyze vast amounts of unstructured data and then provide customers with clinical and financial insights. It was a solid solution built on impressive technology but required a partner to validate and operationalize many of the company’s early claims.

Around that same time, the integrated health system, UPMC, and its payer division, the UPMC Health Plan, were experiencing an influx of new Medicare Advantage enrollments. When coupled with the rollout of additional Affordable Care Act (ACA) product lines, UPMC’s risk adjustment coders simply couldn’t keep up with the overwhelming workload. The health system knew that its current process of manually reviewing charts and identifying risk conditions meant a fragmented workflow and poor productivity. It needed a better way to manage risk.

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UPMC Initiatives

We also seek to attract new ideas, technologies, and opportunities from various internal and external channels, including our innovative partners in Pittsburgh, to help enable and expand our portfolio of commercial businesses, ultimately allowing us to offer solutions that add the most value to those who utilize them.

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The MyUPMC app is the digital front door to UPMC. Its goal is to put patients’ health information right where they need it most. The app allows UPMC patients to get virtual care, message their doctor, make appointments, renew prescriptions and more.

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Together UPMC, Carnegie Mellon University (CMU), and University of Pittsburgh have aligned to help mine data and provide to medical researchers and practitioners to make real life benefits to people. Using world-class computer science expertise from CMU, medical research experts from University of Pittsburgh, and UPMC with deep data, the clinical setting, and a positive record of successful commercialization this Alliance helps those who wish to change the practice of medicine.

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The Center for Connected Medicine (CCM) at UPMC is defining the future of the modern health system through programming that informs, connects, and inspires leaders and innovators in health care. Collaborating with a network of experts from across the health care ecosystem, the CCM focuses its research and events on consumer-centered solutions, digital transformation, and scientific and medical innovation.

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Rx Express

UPMC Rx Express is an AI-powered virtual assistant, CRM platform, and clinical service for pharmacy. Built at UPMC Enterprises in partnership with UPMC Community Provider Services, UPMC Rx Express scales pharmacy operations, improves patient experience, and impacts clinical outcomes, including medication adherence and readmissions. UPMC Rx Express is live at ten hospitals and eleven retail pharmacies, serving upwards of 50,000 patients each year.

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Alexandria Charts

Optimized for health care and trusted for over a decade, Alexandria Charts provides developers with a robust data platform and APIs to build and accelerate the next generation of health care solutions. This platform allows applications to finally unlock the 50-80% of patient data captured in unstructured clinical notes, progress notes, charts, narratives, and referral documents. Alexandria Charts makes it easy for teams to aggregate, normalize, comprehend, and transform unstructured data into high-quality, consumable data.

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Safar TeleCare

UPMC envisioned a forward-thinking distributed model of managing specialist consults virtually, creating Safar TeleCare. Safar TeleCare is a lightweight and intuitive workflow management platform that connects clinical specialists to bedside clinicians virtually across multiple service lines at UPMC. Safar TeleCare’s alignment with the physician workflow has helped improve clinical outcomes and reduce patient-care delays by reducing specialist consultation wait times, removing technology barriers to adoption, and streamlining documentation.

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ParlaiQ is a digital rounding tool developed to improve outcomes by fostering communication between patients and nurses. Developed and refined at UPMC, more than 50 inpatient and outpatient facilities use ParlaiQ to increase patient engagement in order to improve HCAHPS results and hospital rankings through service recognition, custom content, and reports.