Transforming ideas into thriving businesses and life changing medicine


At UPMC Enterprises, we help create health care innovations that impact the lives of patients in meaningful, lasting ways. We provide our portfolio companies and partners with capital, connections, and resources to develop solutions to health care’s most complex problems. To deliver on this promise, we’ve chosen two focus areas where our insights about health care’s future give us a unique advantage.

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Translational Sciences

Investing in and supporting the development and commercialization of cutting-edge diagnostics and therapeutics.

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Digital Solutions

Providing strategic, technical, and financial insights to build innovative products and launch novel technologies.

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From the Blog

Meet the Executive: Chris Katz, Vice President of Consumer Digital Strategy & Operations


We’ve assembled a team of leaders with deep domain knowledge, a keen eye for talent, and a passion for building growing, thriving businesses.

Join our team

At UPMC Enterprises, our vision is advancing health care technology to improve lives. United by our diverse backgrounds, we collaborate to draw upon each other’s unique skills and expertise. Together, we are making a big difference in a big landscape. We are changing health care — for the better.


As the innovation, commercialization, and venture capital arm of UPMC, a $26 billion health care provider and insurer, we maintain a flexible investment model. We can tailor the size of an investment to the situation and are looking to partner with entrepreneurs and companies at all stages to make a significant impact on patient care. We have a diverse portfolio, supporting both early and growth stage companies that fall within our current strategic priorities.

See our complete portfolio

Human Antibodies for Therapeutic Targeting

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Empowering patients to record and understand their health care stories.

Addressing acute respiratory failure

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Using technology-enabled clinical services to address the needs of high-risk populations

Improving affordability and access through provider, care team, and patient technologies.

Advanced analytics in value based care, with a strong NLP focus

Avista Therapeutics

Developing innovative gene therapies for retinal diseases and rare ophthalmic conditions.


Rapid, Personalized T-cell Therapies for Cancer

Improving access to cognitive health care and screening for Alzheimer’s and related dementias.

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Democratizing health care by making medical imaging accessible to everyone around the world.

An end-to-end comprehensive pharmacy solution to drive better clinical and financial outcomes.

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Member management software and services for health plans

Developing the newest treatments for brain diseases using NETSseq

Scalable data platform for healthcare that enables real-time insights into clinical, operational, an…

Leveraging a novel proprietary multivalent synthetic DNA delivery platform, 3DNA, to overcome many o…

Delivers software solutions that streamline the exchange and processing of healthcare information in…

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Value-based care and IDFS development

Developing first-in-class therapeutics that engage validated disease targets

UPMC Enterprises participated in a $5 million Series A investment round in 2018 for Globin Solutions…

Distributed ledger innovation firm improving information trust and transparency.

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Infectious disease consultation, treatment and access via telemedicine solutions

Provider search, scheduling, and data management solutions.

Exchanging clinical data to facilitate collaboration between payers and providers.

Clinical-stage biotech company focused on CNS disorders.

Discovering novel therapeutic targets to develop effective treatments for cancers.

Improving patient outcomes by scaling perioperative optimization and guiding patients through their …

Unlocking the value of clinical data through market-leading software, the largest team of clinical d…

Combining the latest in AI technology with clinical expertise to drive better outcomes.

Powering innovation in health care by developing technologies, tools, and insights that lower the ba…

Powering a new era of gene therapy by leveraging the human commensal virome.

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Predictive analytics, medication adherence, and clinical services

Bringing behavior-based, individualized copays to healthcare.

Building new pathways to connect patients and providers between office visits.

Reducing barriers between information and care.

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Transforming the obstructive sleep apnea space through artificial intelligence and machine learning….

Translating Pioneering Science into Vision-Saving Treatments.

Next generation sequencing and clinical molecular services

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Advancing a pipeline of next-generation, transformative immuno-stimulatory medicines for cancer pati…

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Digital prescribing and analytics platform