Transforming 
ideas into thriving 
businesses and life changing medicine
Focused
At UPMC Enterprises, we help create health care innovations that impact the lives of patients in meaningful, lasting ways. We provide our portfolio companies and partners with capital, connections, and resources to develop solutions to health care’s most complex problems. To deliver on this promise, we’ve chosen two focus areas where our insights about health care’s future give us a unique advantage.
Translational Sciences
Investing in and supporting the development and commercialization of cutting-edge diagnostics and therapeutics.
Digital Solutions
Providing strategic, technical, and financial insights to build innovative products and launch novel technologies.
Empowered
We’ve assembled a team of leaders with deep domain knowledge, a keen eye for talent, and a passion for building growing, thriving businesses.
Join our team
At UPMC Enterprises, our vision is advancing health care technology to improve lives. United by our diverse backgrounds, we collaborate to draw upon each other’s unique skills and expertise. Together, we are making a big difference in a big landscape. We are changing health care — for the better.
CareersDiverse
As the innovation, commercialization, and venture capital arm of UPMC, a $26 billion health care provider and insurer, we maintain a flexible investment model. We can tailor the size of an investment to the situation and are looking to partner with entrepreneurs and companies at all stages to make a significant impact on patient care. We have a diverse portfolio, supporting both early and growth stage companies that fall within our current strategic priorities.
See our complete portfolio
Delivering AI technology that summarizes medical conversations into clinical documentation.
Delivering patient-centered services and personalized programs for a seamless transition to value-ba…
Improving affordability and access through provider, care team, and patient technologies.
Offering HEDIS®-focused software for health plan quality initiatives to achieve value-based care ac…
Developing innovative gene therapies for retinal diseases and rare ophthalmic conditions.
Creating TCR T-cell therapies that harness the immune response of patients to cure cancer.
Improving access to cognitive health care and screening for Alzheimer’s and related dementias.
Democratizing health care by making medical imaging accessible to everyone around the world.
Providing an end-to-end comprehensive pharmacy solution to drive better clinical and financial outco…
Revolutionizing clinical data management by combining AI-driven abstraction with advanced analytics.
Medicare Advantage member acquisition and enrollment technology powered by automation and CMS commun…
Developing the newest treatments for central nervous system disorders using NETSseq.
Scalable health care data platform that enables real-time insights into clinical, operational, and f…
Developing a transformational, new class of precision genetic medicines to treat life-threatening di…
Delivering software solutions that improve health care business functions by optimizing patient data…
A digital health platform for navigating menopause that incorporates telemedicine care, evidence-bas…
Optimizing virtual care workflows at health systems and clinics nationwide.
Partnering with payers and providers to reduce the total cost of care, improve clinical quality, and…
Building a first-in-class pipeline of small molecules to address shortcomings of biologics and impro…
Supporting primary care physicians in providing effective, comprehensive chronic pain management.
Focusing on the development of breakthrough antidotal therapies for human poisonings.
A venture studio driving innovation and collaboration in health care.
Testing the use of peptide nucleic acids to target disease-causing mutations, primarily Huntington 
Providing access to infectious disease expertise through telemedicine solutions.
Connecting the health care ecosystem through provider search, scheduling, and data management soluti…
A clinical-stage company developing innovative non-opioid pain medicines with best-in-class profiles…
A health tech company dedicated to advancing research and ensuring timely access to clinically relev…
Exchanging data to facilitate collaboration between payers and providers through patient-centric int…
Developing CD8 Treg modulators for the treatment of autoimmune and inflammatory diseases.
Clinical-stage biotech company developing therapies for debilitating disorders of the central nervou…
Discovering novel therapeutic targets to develop effective treatments for cancers.
Developing immune reset therapeutics for people living with chronic immune-mediated diseases.
Delivering DME to patients quickly and reliably through an ePrescribing platform for medical equipme…
A population health monitoring and management platform that is scalable across rising and high-risk …
Optimizing the surgical journey for patients, care teams, and physicians to improve outcomes and pat…
Unlocking the value of clinical data through market-leading, enterprise-class data management softwa…
Developing technologies, tools, and insights that lower the barriers to change across the health car…
Cloud-based enterprise platform equipping the health care system with transformational technology to…
Revolutionizing programmable medicines with a commensal virus platform.
Providing predictive analytics, medication adherence, and clinical services to payers and value-base…
Motivating healthy medication behavior through individualized pricing for copays.
Creating efficiency between health care organizations and individuals by reducing barriers between i…
Transforming the obstructive sleep apnea space through artificial intelligence and machine learning….
Translating pioneering science into vision-saving treatments.
A leading operator of medical daycare centers for children with medical complexities.
Designing and developing novel medicines targeting TYK2 to transform patients’ lives.
A transition to practice education solution for NPs, PAs, and the facilities that employ them.
Improving outcomes for patients with heart failure through the development of AI-based solutions.
Advancing a pipeline of next-generation, transformative immuno-stimulatory medicines for cancer pati…
Enabling providers to easily prescribe and monitor digital health content.
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